One‐Pot Synthesis of Polysubstituted Benzenes through a N,N‐dimethyl‐4‐aminopyridine (DMAP)‐Catalyzed [4+2] Benzannulation of 1,3‐Bis(sulfonyl)butadienes and γ‐Substituted Allenoates |
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| Authors: | Meijia Chang Chengzhou Wu Jie Zheng Prof You Huang |
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| Institution: | 1. State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin, China;2. (+86)?22‐23503159;3. Collabortive Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin, China |
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| Abstract: | A new strategy for the one‐pot synthesis of polysubstituted benzenes through a N,N‐dimethyl‐4‐aminopyridine (DMAP)‐catalyzed 4+2] benzannulation from readily prepared 1,3‐bis(sulfonyl)butadienes and γ‐substituted allenoates is described. This method provides a facile, metal‐free and general route to highly substituted benzenes under mild conditions in moderate‐to‐good yields with complete regioselectivity. |
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| Keywords: | benzannulation domino reactions organocatalysis polysubstituted benzenes γ -substituted allenoates |
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