An Approach for the Selective Detection of Nitric Oxide in Biological Systems: An in vitro and in vivo Perspective |
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| Authors: | Neha Gupta Shahi Imam Reja Dr. Vandana Bhalla Muskan Gupta Prof. Gurcharan Kaur Prof. Manoj Kumar |
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| Affiliation: | 1. Department of Chemistry, Guru Nanak Dev University, Amritsar, India;2. Department of Biotechnology, Guru Nanak Dev University, Amritsar, India |
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| Abstract: | A naphthalimide‐based fluorescent probe, LyNP‐NO , was designed and synthesized for the selective detection of exogenously and endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP‐NO was also explored for monitoring endogenous NO levels in rat hippocampus at various tissue depths by stimulating the brain with N‐methyl‐d ‐aspartate (NMDA). |
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| Keywords: | biological activity imaging agents fluorescent probes lysosomes nitric oxide |
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