Synthesis of N-acetyl derivatives of 5-and 6-ethoxy-2-methylthiobenzimidazole and their cardiotonic activity

The regioselectivity of the N-acetylation of 5-and 6-ethoxy-2-methylthiobenzimidazole for various acetylating agents under various conditions has been investigated. The cardiotonic activity of the 1-acetyl-5-ethoxy-and 1-acetyl-6-ethoxy-2-methylthiobenzimidazoles synthesized and of their 5,6-diethoxy analog has been studied.Vilnius University, Vilnius LT-2006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 765–771, June, 1997.