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Enantioselective heterogeneous catalytic production of alpha-amino acids |
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| Authors: | Marlito Gomes Jr. R. Hernández-Valdés Carlos E. S. J. Marques Marcelo L. Bastos Donato A. G. Aranda O. A.C. Antunes |
| Affiliation: | (1) IQ-UFRJ, Rio de Janeiro, RJ 21945-970, Brazil,;(2) IQ-UFRJ NPPN-UFRJ, Rio de Janeiro, RJ 21945-970, Brazil, Rio de Janeiro, RJ 21945-970, Brazil,;(3) IQ-UFRJ, Rio de Janeiro, RJ 21945-970, Brazil,;(4) IQ-UFRJ Depto. de Química Organica, Faculdade de Farmácia, Universidade Estácio de Sá, Rio de Janeiro, RJ 21945-970, Brazil, Rio de Janeiro, RJ 20261-063,;(5) EQ-UFRJ, Rio de Janeiro, RJ 21945-970, Brazil;(6) IQ-UFRJ NPPN-UFRJ, Rio de Janeiro, RJ 21945-970, Brazil Rio de Janeiro, RJ 21945-970, Brazil, |
| Abstract: | Summary In the present paper the heterogeneous catalytic preparation of alpha-amino acids by hydrogenation of the dehydroamino acids catalyzed by palladium is described. Enantiomeric excess of up to 26% was achieved when the hydrogenation was carried out in ethanol at 0.5 MPa, 298 K with substrate concentration kept at 80 mmol L-1, 50 mol% cinchonidine as modified and triethylamine as addictive. |
| Keywords: | hydrogenation cinchona alkaloids Chiral catalysis amine addition |
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