| Synthesis of 1-aryl-3-（3,4-dihydro-2H-chromen-5-yl） ureas as TNF-α inhibitors |
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| 引用本文： | Xin Ming Zhou Zhi Bing Zheng Hong Ying Liu Wu Zhong Jun Hai Xiao Li Li Wang Song Li. Synthesis of 1-aryl-3-（3,4-dihydro-2H-chromen-5-yl） ureas as TNF-α inhibitors[J]. 中国化学快报, 2007, 18(8): 905-908. DOI: 10.1016/j.cclet.2007.06.014 |
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| 作者姓名： | Xin Ming Zhou Zhi Bing Zheng Hong Ying Liu Wu Zhong Jun Hai Xiao Li Li Wang Song Li |
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| 作者单位： | a，* |
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| 摘 要： | A new series of compounds,1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas,have been synthesized and their structures were confirmed by FAB-MS and ~1H NMR.The preliminary pharmacological screening showed that these compounds inhibited TNF-αproduction in lipopolysaccharide (LPS)-stimulated THP-1 cells.
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| 关 键 词： | p38 MAPK抑制剂 1-芳基-3-（3 4-二氢-2H-色烯-5-基）尿素 合成 结构分析 |
| 收稿时间： | 2007-04-16 |
| 修稿时间： | 2007-04-16 |
Synthesis of 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas as TNF-α inhibitors |
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| Xin Ming Zhou,Zhi Bing Zheng,Hong Ying Liu,Wu Zhong,Jun Hai Xiao,Li Li Wang,Song Li,. Synthesis of 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas as TNF-α inhibitors[J]. Chinese Chemical Letters, 2007, 18(8): 905-908. DOI: 10.1016/j.cclet.2007.06.014 |
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| Authors: | Xin Ming Zhou Zhi Bing Zheng Hong Ying Liu Wu Zhong Jun Hai Xiao Li Li Wang Song Li |
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| Affiliation: | 1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | A new series of compounds, 1-aryl-3-(3,4-dihydro-2H-chromen-5-yl) ureas, have been synthesized and their structures were confirmed by FAB-MS and 1H NMR. The preliminary pharmacological screening showed that these compounds inhibited TNF-α production in lipopolysaccharide (LPS)-stimulated THP-1 cells. |
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| Keywords: | p38 MAPK inhibitor 1-Aryl-3-(3 4-dihydro-2H-chromen-5-yl) ureas Synthesis |
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