| Interaction between N-phosphoryl-α, β- and γ-amino acids and nucleosides |
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| 作者姓名： | Li Ming Qiang Shu Xia Cao Yan Chun Guo Xin Cheng Liao Yu Fen Zhao |
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| 作者单位： | a，b，* |
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| 基金项目： | The authors would like to thank the National Natural Science Foundation of China （Nos. 20572061,20672104）, the Chinese Ministry of Education and Zhengzhou University for financial support. |
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| 摘 要： | The reactions of four different N-(O,O′-diisopropyl) phosphoamino acids (DIPP-aa),such as N-phosphoryl-L-α-alanine (DIPP- L-α-Ala),N-phosphoryl-D-α-alanine (DIPP-D-α-Ala),N-phosphoryl-β-alanine (DIPP-β-Ala) and N-phosphoryl-γ-amino butyric acid (DIPP-γ-Aba),and four nucleosides,adenosine (A),guanosine (G),cytidinc (C) and uridine (U),were studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and HPLC/ESI-MS.DIPP-L-α-Ala and DIPP-D-α-Ala produced the same phosphorylated nucleosidcs,dinucleotidcs and phosphoroligopeptide.However,DIPP-β-Ala and DIPP-γ-Aba gave no relevant products.
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| 关 键 词： | N-磷酰基氨基酸 核苷 二核苷酸 γ-氨基酸 |
| 收稿时间： | 24 January 2007 |
| 修稿时间： | 2007-01-24 |
Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides |
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| Li Ming Qiang Shu Xia Cao Yan Chun Guo Xin Cheng Liao Yu Fen Zhao.Interaction between N-phosphoryl-α-, β- and γ-amino acids and nucleosides[J].Chinese Chemical Letters,2007,18(8):939-942. |
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| Authors: | Li Ming Qiang Shu Xia Cao Yan Chun Guo Xin Cheng Liao Yu Fen Zhao |
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| Institution: | 1. Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China;2. Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China |
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| Abstract: | The reactions of four different N-(O,O′-diisopropyl) phosphoamino acids (DIPP-aa), such as N-phosphoryl-l-α-alanine (DIPP-l-α-Ala), N-phosphoryl-d-α-alanine (DIPP-d-α-Ala), N-phosphoryl-β-alanine (DIPP-β-Ala) and N-phosphoryl-γ-amino butyric acid (DIPP-γ-Aba), and four nucleosides, adenosine (A), guanosine (G), cytidine (C) and uridine (U), were studied by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and HPLC/ESI-MS. DIPP-l-α-Ala and DIPP-d-α-Ala produced the same phosphorylated nucleosides, dinucleotides and phosphoroligopeptide. However, DIPP-β-Ala and DIPP-γ-Aba gave no relevant products. |
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| Keywords: | N-phosphoryl amino acids Nucleosides Dinucleotides |
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