| Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes |
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| 引用本文： | Kun Zou Jun Zhi Wang Jun Wu Yuan Zhou Chuang Liu Fei Jun Dan Ya Xiong Zhang Jin Yang. Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes[J]. 中国化学快报, 2007, 18(10): 1239-1242. DOI: 10.1016/j.cclet.2007.06.018 |
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| 作者姓名： | Kun Zou Jun Zhi Wang Jun Wu Yuan Zhou Chuang Liu Fei Jun Dan Ya Xiong Zhang Jin Yang |
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| 作者单位： | a，* |
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| 摘 要： | Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes,a folk medicine of Shennongjia Forest District of Hubei Province.Their structures were determined as (25S)-26-O-(β-D-glucopyranosyl)- furost-1β,3β,22α,26-tetrol-3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glucopyranoside (1) and (25R)- 26-O-(β-D-glucopyranosyl)-furost-1β,3β22α,26-tetrol 3-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranosyl-(1→2)-β-D-glu- copyranoside (2),on basis of chemical and spectroscopic evidences.1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20μg/mL.
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| 关 键 词： | 皂角苷 COX-2 医学 药理 |
| 收稿时间： | 2007-03-12 |
| 修稿时间： | 2007-03-12 |
Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes |
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| Kun Zou,Jun Zhi Wang,Jun Wu,Yuan Zhou,Chuang Liu,Fei Jun Dan,Ya Xiong Zhang,Jin Yang. Furostanol saponins with inhibitory action against COX-2 production from Tupistra chinensis rhizomes[J]. Chinese Chemical Letters, 2007, 18(10): 1239-1242. DOI: 10.1016/j.cclet.2007.06.018 |
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| Authors: | Kun Zou Jun Zhi Wang Jun Wu Yuan Zhou Chuang Liu Fei Jun Dan Ya Xiong Zhang Jin Yang |
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| Affiliation: | 1. Hubei Province Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Sciences, China Three Gorges University, Yichang 443002, China;2. Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China |
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| Abstract: | Two furostanol saponins were obtained from the n-butanol fraction of methanol extract from Tupistra chinensis rhizomes, a folk medicine of Shennongjia Forest District of Hubei Province. Their structures were determined as (25S)-26-O-(β-d-glucopyranosyl)-furost-1β, 3β, 22α, 26-tetrol-3-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside (1) and (25R)-26-O-(β-d-glucopyranosyl)-furost-1β, 3β 22α, 26-tetrol 3-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranosyl-(1 → 2)-β-d-glucopyranoside (2), on basis of chemical and spectroscopic evidences. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophages of the rat abdomen induced by LPS at 20 μg/mL. |
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| Keywords: | Tupistra chinensis Bak. Furostanol saponin COX-2 Folk medicines |
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