| Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents |
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| 作者姓名： | Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen |
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| 作者单位： | [1]Key Laboratory of Asymmetric Synthesis ＆ Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China [2]Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
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| 基金项目： | The authors thank the 100 Talents program of Chinese Academy of Sciences, the Chengdu Institute of 0rganic Chemistry, and the Graduate School of the Chinese Academy of Sciences for financial support of this work. |
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| 摘 要： | A variety of indole derivatives were designed,synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines.All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay.The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents.
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| 关 键 词： | 吲哚 合成 驱动蛋白轴蛋白质抑制剂 细胞毒性 癌症处理 |
| 收稿时间： | 9 April 2007 |
| 修稿时间： | 2007-04-09 |
Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents |
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| Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen.Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J].Chinese Chemical Letters,2007,18(8):899-901. |
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| Authors: | Chang Qing Shi Zhang Qin Liu Wen Qing Lin Yuan Wei Chen |
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| Institution: | 1. Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China;2. Graduate School of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | A variety of indole derivatives were designed,synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the A431 and H460 cell lines.All the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay.The findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents. |
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| Keywords: | Indoles Synthesis Kinesin spindle protein inhibitor Cytotoxicity Cancer treatment |
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