| Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries |
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| 引用本文： | Zhen Li Min Yi Hua Zhang Yi Sheng Lai Si Xun Peng. Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries[J]. 中国化学快报, 2007, 18(11): 1361-1363. DOI: 10.1016/j.cclet.2007.09.038 |
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| 作者姓名： | Zhen Li Min Yi Hua Zhang Yi Sheng Lai Si Xun Peng |
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| 作者单位： | Zhen Li Min Yi Hua Zhang Yi Sheng Lai Si Xun Peng Center of Drug Discovery，China Pharmaceutical University，Nanjing 210009，China |
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| 摘 要： | A new approach for asymmetric syntheses of (S) and (R)-3-n-butylphthalide (NBP) is presented.The diastereoselective addition of dibutylzinic to aromatic aldehyde 10 or 11 generated from isomannide-or isosorbide-derived chiral auxiliary afforded S-NBP or R-NBP in high optical yields.
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| 关 键 词： | 不对称合成 异构体 化学反应 醛 |
| 收稿时间： | 2007-07-23 |
| 修稿时间： | 2007-07-23 |
Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries |
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| Zhen Li Min,Yi Hua Zhang,Yi Sheng Lai,Si Xun Peng. Asymmetric synthesis of 3-butylphthalide using isomannide and isosorbide as chiral auxiliaries[J]. Chinese Chemical Letters, 2007, 18(11): 1361-1363. DOI: 10.1016/j.cclet.2007.09.038 |
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| Authors: | Zhen Li Min Yi Hua Zhang Yi Sheng Lai Si Xun Peng |
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| Affiliation: | Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | A new approach for asymmetric syntheses of (S) and (R)-3-n-butylphthalide (NBP) is presented.The diastereoselective addition of dibutylzinic to aromatic aldehyde 10 or 11 generated from isomannide-or isosorbide-derived chiral auxiliary afforded S-NBP or R-NBP in high optical yields. |
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| Keywords: | Asymmetric synthesis 3-n-Butylphthalide Isomannide Isosorbide |
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