| Stereoselective Synthesis of (±) Neocnidilide |
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| 作者姓名： | Xiao Zhen JIAO Ping XIE* Lian Suo ZU Xiao Tian LIANG Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing |
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| 作者单位： | Xiao Zhen JIAO，Ping XIE*，Lian Suo ZU，Xiao Tian LIANG Institute of Materia Medica，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100050 |
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| 摘 要： | The lactone neocnidilide 8 occur in the roots of Cnidilide officinale1 which is shown to inhibit the growth and toxin production of mycotoxin-producing fungi2. Although The synthesis of lactones 7, which is stereoisomer of cnidilide, and 8 had been reported by others3, 4, we would like to report the highly stereoselective synthesis of its racemic isomer 8 as shown in Scheme 1. Scheme 1 COOHHOOCbcOOHH1234d5eOHOHHH 6fOOHHH 7g8COOHOHa12345673a7aOHHOH1235673 a7a1234561'1'2'…
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Stereoselective Synthesis of (±) Neocnidilide |
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| Xiao Zhen JIAO,Ping XIE*,Lian Suo ZU,Xiao Tian LIANG Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing .Stereoselective Synthesis of (±) Neocnidilide[J].Chinese Chemical Letters,2003,14(2). |
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| Authors: | Xiao Zhen JIAO Ping Xie Lian Suo ZU Xiao Tian LIANG |
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| Abstract: | The racemic neocnidilide has been synthesized by stereoselective reaction of hemiacetal 5 with n-BuMgBr. |
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| Keywords: | Neocnidilide stereoselective synthesis |
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