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A short stereoselective synthesis of (+)-aza-galacto-fagomine (AGF) |
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| Authors: | Jasna Marjanovic Trajkovic Zorana Ferjancic Radomir N Saicic |
| Institution: | 1. Faculty of Chemistry, University of Belgrade, Studentski trg 16, POB 51, 11158 Belgrade 118, Serbia;2. Innovation Centre, Faculty of Chemistry, 11000 Belgrade, Serbia |
| Abstract: | A catalytic asymmetric synthesis of (+)-aza-galacto-fagomine (AGF) – the most promising compound for the pharmacological chaperone therapy of Krabbe disease – was accomplished in six steps, in 14% overall yield. The synthesis hinges on the combination of organocatalyzed aldolization and reductive hydrazination. |
| Keywords: | Aza-galactofagomine Organocatalysis Krabbe disease Enantioselective synthesis Azasugars |
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