Diastereoselective synthesis of dihydroindolizin-3(2H)-one derivatives via catalytic sulfur-Michael addition triggered intramolecular tandem sequence |
| |
Authors: | Shi-Qiang Zhang Yan Yan Wei Liu Wei-Wei Liao |
| |
Institution: | 1. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, PR China;2. State Key Lab of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, PR China |
| |
Abstract: | A diastereoselective synthesis of functionalized dihydroindolizidine derivatives bearing sulfur moiety was reported with high stereoselectivity via a catalytic sulfur-Michael addition triggered intramolecular aldol-type tandem sequence. This protocol allowed to readily access trans- and cis-dihydroindolizidine products in high yields with moderate to excellent diastereoselectivities under the optimized mild reaction conditions, which also can be easily transformed into various substituted functionalized pyridines incorporating β-quaternary carbon centers. |
| |
Keywords: | Michael addition Tandem sequence Dihydroindolizidine Diastereoselective synthesis |
本文献已被 ScienceDirect 等数据库收录! |