Cation exchange media provide a multi-stage,orthogonal catch and release method for MIDA boronates bearing basic centers

An operationally simple and rapid purification of MIDA boronates is described. This method allows separation of MIDA boronates containing basic centers from those that are neutral as well as separation from species that do not contain the MIDA moiety using a single “catch and release” purification medium. Application of this method to the purification of reductive amination products is described. It is hoped that this facile, rapid and conceptually new isolation will stimulate further investigation of other functionalized silica gel media for the isolation of MIDA boronate building blocks.