Multicomponent reactions (MCRs) of arylmethyl bromides,arylamidines and elemental sulfur toward unsymmetric 3,5-diaryl 1,2,4-thiadiazoles |
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| Authors: | Zhen Zhou Miaochang Liu Song Sun En Yao Suqin Liu Zhiwen Wu Jin-Tao Yu Yan Jiang Jiang Cheng |
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| Affiliation: | 1. School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and Institute for Natural and Synthetic Organic Chemistry, Changzhou University, Changzhou 213164, PR China;2. College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325000, PR China |
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| Abstract: | A base-promoted three-component reaction between arylmethyl bromides, arylamidines and elemental sulfur was developed, leading to unsymmetric 3,5-diaryl-1,2,4-thiadiazoles in moderate to good yields with chemical diversity and complexity. This procedure shows broad substrates scope by employing elemental sulfur and commercially available starting materials under transition-metal free conditions. |
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| Keywords: | Transition-metal free Elemental sulfur Multicomponent reactions 1,2,4-Thiadiazoles |
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