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The first total synthesis of usabamycins a and C |
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| Authors: | Guna Sakaine Ronalds Zemribo Gints Smits |
| Affiliation: | Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia |
| Abstract: | The first total synthesis of usabamycins A and C from inexpensive and readily available amino acids – homoalanine and glycine and featuring a stereoselective Ireland-Claisen rearrangement as well as a novel 7-membered ring formation reaction is described. |
| Keywords: | Pyrrolo[14]benzodiazepines Anti cancer agents Natural products Usabamycin A Usabamycin C Ireland-Claisen rearrangement |
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