Copper-catalyzed annulation of 2-bromobenzoic esters with terminal alkynes towards 3-substituted isocoumarins |
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| Authors: | Mengli Sun Lebin Su Jianyu Dong Long Liu Yongbo Zhou Shuang-Feng Yin |
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| Institution: | State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China |
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| Abstract: | An efficient method for the synthesis of 3-substituted isocoumarins that are an important class of biologically active scaffolds via annulation of 2-bromobenzoic esters with terminal alkynes by copper catalyzed is described. The advantages of this method include mild reaction conditions, high yield and regioselectivity, and wide tolerance toward functional groups. |
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| Keywords: | Isocoumarins Copper catalysis Terminal alkynes 2-Bromobenzoic esters |
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