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A one-pot,two-step synthesis of 3-deazacanthin-4-ones via sequential Pd-catalyzed Suzuki-Miyaura and Cu-catalyzed Buchwald-Hartwig reactions |
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| Authors: | Emmanouil Broumidis Panayiotis A. Koutentis | |
| Affiliation: | Department of Chemistry, University of Cyprus, P. O. Box 20537, 1678 Nicosia, Cyprus | |
| Abstract: | 3-Deazacanthin-4-one and nine analogues, including the 8-aza analogue, were prepared rapidly and in high yields from 8-iodoquinolones and 2-chloro(het)arylboronic acids. The strategy involves construction of the central B ring via concomitant Pd-catalyzed Suzuki-Miyaura C | |
| Keywords: | Canthine alkaloids Nitrogen heterocycles Suzuki-Miyaura reaction Buchwald-Hartwig reaction Transition-metal catalysis | |
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