| 一个新的肿瘤相关基因-CYP2C 1 9 |
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| 引用本文： | 陈枢青,赵鲁杭,金百冶.一个新的肿瘤相关基因-CYP2C 1 9[J].宁波大学学报(理工版),2000,13(3):13-15. |
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| 作者姓名： | 陈枢青 赵鲁杭 金百冶 |
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| 作者单位： | 1. 宁波大学 医学院，浙江 宁波 315211
2. 浙江大学 医学院，浙江 杭州 310006 |
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| 基金项目： | 浙江省自然科学基金(396473)资助． |
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| 摘 要： | 细胞色素Ｐ４５０ ２Ｃ１９（ＣＹ２Ｃ１９）又称为Ｓ－美芬妥英羟化酶，它的两个突变型等位基因ＣＹＰ２Ｃ１９ｍ１和ＣＹＰ２Ｃ１９ｍ２是引起ＣＹＰ２Ｃ１９酶活性缺陷的原因，运用等位基因特异扩增法（ＡＳＡ）对肺癌患者、膀胱癌患者及正常人进行了ＣＹＰ２Ｃ１９基因分型研究，以探索ＣＹＰ２Ｃ１９酶活性与肺癌、膀胱癌易患性的关系，经过对７４例肺癌患者、５０例膀胱癌患者和７０例对照组的测定，发现肺癌组慢代射的发生率
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| 关 键 词： | CYP2C19基因 肿瘤相关基因 肺癌 膀胱癌 |
| 文章编号： | 1001-5132(2000)03-0013-03 |
| 修稿时间： | 2000年4月28日 |
A New Tumor-Related Gene-CYP2C19 |
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| Chen Shu-qing,ZHAO Lu-hang,JIN Bai-ye.A New Tumor-Related Gene-CYP2C19[J].Journal of Ningbo University(Natural Science and Engineering Edition),2000,13(3):13-15. |
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| Authors: | Chen Shu-qing ZHAO Lu-hang JIN Bai-ye |
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| Abstract: | Cytochrome P450 2C19(CYP2C19, S-mephenytoin hydroxylase) enzyme deficiency was caused by two mutant alleles: CYP2C19ml and CYP2C19m2. An allele-specific amplification based CYP2C19 genotyping method was employed to analyze 74 cases of lung cancer patients, 50 cases of bladder cancer patients and a control group with 70 healthy subjects. It was found that the frequency of poor metabolizers of CYP2C19 was 32.4% in lung cancer group, 4.0% in bladder cancer group and 15.7% in control group. There were extremely statistic differences between control group and experimental groups. Poor metabolisers of CYP2C19 had an increased risk of lung cancer, but had a decreased risk of bladder cancer. It suggested that CYP2C19 is a new tumor-related gene and the enzyme may participate in the inactivation of carcinogens of lung cancer and the activation of procarcinogens of bladder cancer. |
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| Keywords: | CYP2C19 gene tumor-related gene lung cancer bladder cancer |
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