Application of a chemometric method for simultaneous determination of acetaminophen and diclofenac in content-uniformity and drug-dissolution studies |
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| Authors: | Patricia?M?Castellano Silvana?E?Vignaduzzo Rubén?M?Maggio Email author" target="_blank">Teodoro?S?KaufmanEmail author |
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| Institution: | (1) Area Análisis de Medicamentos, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario (S2002LRK), Argentina;(2) Instituto de Química Orgánica de Síntesis -IQUIOS- (CONICET-UNR), Suipacha 531, Rosario (S2002LRK), Argentina |
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| Abstract: | A new, repeatable, and rapid method has been developed for resolution of binary mixtures of acetaminophen and diclofenac with minimum sample pretreatment and without separation of the analytes. The method, based on the PLS1 processing of absorbance data in the UV region, was successfully used for quantification of the drug content of three tablet preparations. The results obtained were in good agreement with HPLC recovery data. The method also enabled determination of drug-dissolution profiles of these commercial tablets, by simultaneous determination of both analytes during the dissolution test. |
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| Keywords: | Chemometric method Acetaminophen Diclofenac PLS Dissolution |
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