Method validation and reference materials |
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Authors: | Margreet Lauwaars Elke Anklam |
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Institution: | (1) European Commission, Directorate General Joint Research Centre, Institute for Reference Materials and Measurements, Food Safety and Quality Unit, Retieseweg 111, 2440 Geel, Belgium |
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Abstract: | For implementation of food and feed legislation, there is a strong need for development and harmonisation of reliable, validated and if possible, robust and simple analytical methods. In addition, precise methods used for measuring the exposure of humans to certain types of food contaminants and residues (natural, man-made or produced during technological treatment) such as, e.g. mycotoxins, acrylamide, pesticides and allergens have to be available, in order to compare results derived from monitoring studies. Methods should be validated (in-house or in a collaborative trial) according to harmonised protocols and good laboratory practice must be in place in order to be compliant with internationally harmonised standards. The way in which this is implemented depends strongly on the analyte, interference within the food matrix and other requirements that need to be met. Food and feed certified reference materials, when matrix matched and containing the appropriate concentration of the certified substance, are an extremely useful tool in validation of measurements.Presented at BERM-9—Ninth International Symposium on Biological and Environmental Reference Materials, 15–19 June 2003, Berlin, Germany. |
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Keywords: | Food analysis Food safety and quality Method validation Certified reference materials |
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