| 2,2-二羟甲基丙二酸二乙酯的化学电离质谱分析 |
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| 引用本文： | 蔡春,张立坚,王秀季,吴勇.2,2-二羟甲基丙二酸二乙酯的化学电离质谱分析[J].分析测试学报,2006,25(2):71-73,76. |
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| 作者姓名： | 蔡春 张立坚 王秀季 吴勇 |
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| 作者单位： | 1. 广东医学院,分析中心,广东,湛江,524023
2. 四川大学,华西药学院,四川,成都,610041 |
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| 摘 要： | 化学电离(chem ical ionization,CI)是由Munson和Field1]于1966年提出的一种质谱电离技术,其原理实际上是分子-离子反应2,3]。在化学电离条件下,常常可以得到丰度很强的准分子离子峰,没有或很少碎片离子,能准确提供相对分子质量信息,但缺乏结构信息。我们在实验中发现,采用适
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| 关 键 词： | 2 2-二羟甲基丙二酸二乙酯 质谱 化学电离技术 |
| 文章编号： | 1004-4957（2006）02-0071-03 |
| 收稿时间： | 2005-03-11 |
| 修稿时间： | 2005-03-112005-11-26 |
CI MS Analysis of Diethyl Bis(hydroxymethyl) Malonate |
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| CAI Chun,ZHANG Li-jian,WANG Xiu-ji,WU Yong.CI MS Analysis of Diethyl Bis(hydroxymethyl) Malonate[J].Journal of Instrumental Analysis,2006,25(2):71-73,76. |
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| Authors: | CAI Chun ZHANG Li-jian WANG Xiu-ji WU Yong |
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| Institution: | 1. Analysis Center, Guangdong Medical College, Zhanjiang 524023, China; 2. West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| Abstract: | Diethyl bis(hydroxymethyl)malonate(DBM) was synthesized and analyzed by chemical ionization mass spectrum(CI MS).The CI MS conditions for obtaining more fragmentation ions in the presence of strong molecular ion peak were studied,and the ion formation pathway was also analyzed.The results showed that under the selected CI conditions,the MS spectra of DBM quasimolecular ion and its fragmentation ions produced in the course of further fragmentation were obtained.These fragmentation ions followed the organic MS ion fragmentation rule.Using the MS fragmentation mechanisms,the fragmentation pathway of these ions could be analyzed.Based on the selected CI conditions,both the sample molecular mass and structure informations could be obtained with good repeatability. |
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| Keywords: | Diethyl bis(hydroxymethyl)malonate Mass spectrum Chemical ionization(CI) |
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