纳米磁性药物靶向动力学模拟

基于Navier-Stokes方程与Maxwell-Ampere理论建立了肿瘤细动脉中血液的非定常脉动模型,在磁场和流场耦合状态下研究引入纳米磁性药物后磁场对血液流场的影响.把离散模型和单相模型耦合,用有限元方法对纳米磁性药物在细动脉中的传输进行动力学模拟.模拟结果表明,磁场对纳米尺度磁性粒子的俘获形式明显不同于对微米尺度粒子,纳米磁性粒子运动轨迹与血液流线基本重合.由于磁性纳米粒子的存在,磁场影响了血液的流场分布,在磁体附近形成涡流区并长期滞留,以此方式实现对磁性药物的俘获.

Dynamical Simulation of Magnetic Nano-drug Targeting

We describe an unsteady flow model of blood in arterioles of normal and tumor tissues,and show effect of external magnetic field on flow field of blood considering coupling of magnetic field and flow. Traditional single-phase model is modified by a discrete method,and dynamical simulation with a finite element route is used to investigate transmission of magnetic nano-drug in arteriole.The result indicates that the capture of nano-drug by magnetic field is entirely different from that of microdrug by magnetic field.The trajectoriy of nano-drug is primarily coincident with the streamline of blood flow.However,the effect of magnetic field on the blood flow is obvious due to the presence of magnetic nano-drug.Several whirlpools are formed near the magnet.In tumor arteriole these whirlpools stay for a long time and the magnetic nano-drug is efficiently captured by external magnetic field.