Three-dimensional structures of OSW-1 and its congener |
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| Authors: | Sakurai Kaori Fukumoto Takuro Noguchi Keiichi Sato Noriyuki Asaka Hiroki Moriyama Naomi Yohda Masafumi |
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| Institution: | Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, 184-8588, Japan. sakuraik@cc.tuat.ac.jp |
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| Abstract: | The 3D structures of an antitumor glycosylsterol OSW-1 and its closely related congener were investigated by NMR studies and an X-ray crystallographic analysis. The disaccharide moiety was found as a structural scaffold for the formation of a hydrophobic cluster by the biologically required functionalities. |
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