| An Efficient Synthesis of Ethyl 7-Chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-[1, 3]thiazeto[3, 2-a]quinoline-3-carboxylate as Intermediate of the Prulifloxacin Containing Tricyclic Fluoroquinolone |
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| 引用本文： | Shu Tao MA,Hong Xiang LOU School of Pharmacy,Shandong University,Jinan 250012. An Efficient Synthesis of Ethyl 7-Chloro-6-fluoro-1-methyl-4-oxo-1,4-dihydro-[1, 3]thiazeto[3, 2-a]quinoline-3-carboxylate as Intermediate of the Prulifloxacin Containing Tricyclic Fluoroquinolone[J]. 中国化学快报, 2006, 17(6) |
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| 作者姓名： | Shu Tao MA Hong Xiang LOU School of Pharmacy Shandong University Jinan 250012 |
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| 作者单位： | Shu Tao MA，Hong Xiang LOU School of Pharmacy，Shandong University，Jinan 250012 |
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| 摘 要： | The fluoroquinolones such as ciprofloxacin and sparfloxacin have been widely used for the treatment of various bacterial infections1. Their mechanism of action is believed to be associated with inhibition of bacterial DNA gyrase2. Moreover, recent studies…
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An Efficient Synthesis of Ethyl 7-Chloro-6-fluoro-1-methyl-4-oxo-1, 4-dihydro-[1, 3]thiazeto[3, 2-a]quinoline-3-carboxylate as Intermediate of the Prulifloxacin Containing Tricyclic Fluoroquinolone |
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| Shu Tao MA,Hong Xiang LOU. An Efficient Synthesis of Ethyl 7-Chloro-6-fluoro-1-methyl-4-oxo-1, 4-dihydro-[1, 3]thiazeto[3, 2-a]quinoline-3-carboxylate as Intermediate of the Prulifloxacin Containing Tricyclic Fluoroquinolone[J]. Chinese Chemical Letters, 2006, 17(6) |
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| Authors: | Shu Tao MA Hong Xiang LOU |
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| Abstract: | Novel ethyl 7-chloro-6-fluoro-1-methyl-4-oxo-1, 4-dihydro-[1, 3]thiazeto[3, 2-a]quino- line-3-carboxylate 2 was prepared from 3-chloro-4-fluoroaniline in eight steps. It can be used as a new intermediate for the synthesis of tricyclic fluoroquinolones. |
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| Keywords: | Synthesis tricyclic fluoroquinolone. |
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