Electrochemical studies of the effect of lanthanide ions on the activity of glutamate dehydrogenase |
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| Authors: | Zhuang Q K Dai H C Gao X X Xin W K |
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| Institution: | Department of Chemistry, Beijing, People's Republic of China. qkzhuang@chemms.chem.pku.edu.cn |
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| Abstract: | Using the electrochemical method based on the "diffusion" layer concept of the convective system, the effect of lanthanide ions La3+ and Eu3+ on the activity of glutamate dehydrogenase (GLDH) has been determined. In suitable concentrations, the lanthanide ions La3+ and Eu3+ can activate the GLDH in the reductive amination of alpha-Ketoglutarate (alpha-KG). The activation mechanism would be that the lanthanide ions could interrupt the binding of NAD+ to GLDH by combining preferentially to NAD+. This mechanism was proposed by the voltammetric studies. |
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