New method for the synthesis of macrocyclic compounds

The intramolecular acylation of acid chlorides of ω-thienylalkanoic acids of various structures in the presence and absence of silica gel was investigated. The reaction of aluminum chloride etherate and the indicated acid chlorides with the surface groups of silica gel was studied by IR spectroscopy, and the role of the compounds formed on the surface in the reaction under consideration was discussed. A sequence of processes and a mechanism involving participation of the solid phase in the intramolecular acylation of acid chlorides of ω-thienylalkanoic acids are formulated.