首页 | 本学科首页   官方微博 | 高级检索  
     检索      


N-Arylation of nitrogen heterocycles with 2,4-difluoroiodobenzene
Authors:Rukkiat Jitchati
Institution:Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK
Abstract:Arylation reactions of NH-heterocycles specifically, pyrazole, 3-(trifluoromethyl)pyrazole, imidazole and pyrrole] with 2,4-difluoroiodobenzene in the absence and presence of copper catalysis are described. The combination of fluoro and iodo substituents in the same aryl substrate has facilitated both SNAr reactions at the C-F bonds and copper-catalysed Ullmann-type coupling reactions at the C-I bond. Products arising from regioselective reactions and multiple substitutions have been isolated, providing a range of new N-arylated pyrazole, imidazole and pyrrole derivatives.
Keywords:Arylation  Nucleophilic aromatic substitution  Pyrazole  Imidazole  Pyrrole  Copper catalysis
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号