Synthesis and tautomeric structure of 6-arylhydrazono 1H-pyrazolo[3′,4′:4,5]pyrimido[1,6-b][1,2,4]triazepines |
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Authors: | Ahmad S Shawali Thoraya A Farghaly |
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Institution: | Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt |
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Abstract: | A simple synthetic strategy is described for synthesis of the hitherto unreported 6-arylhydrazono-1,3-diphenyl-7-methyl-1H-pyrazolo3′,4′:4,5]pyrimido1,6-b]1,2,4]triazepin-5(6H)-ones 5a-j. The acid dissociation constants were determined for the series prepared and were correlated by the Hammett equation using the enhanced substituent constants. The results of such a correlation together with the spectral data indicated that the studied compounds exist predominantly in the hydrazone tautomeric form. |
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Keywords: | Azo-hydrazone tautomerism Heterocycles Pyrazolo[3&prime 4&prime :4 5]pyrimido[1 6-b]triazepine |
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