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The first synthesis of ent-agelasine F |
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| Authors: | Ágnes Proszenyák Colin Charnock |
| Institution: | a Department of Chemistry, University of Oslo, PO Box 1033, Blindern, N-0315 Oslo, Norway b Research and Development, Pronova BioPharma Norge AS, PO Box 2109, N-3202 Sandefjord, Norway c Faculty of Health Sciences, Oslo University College, PO Box 4, St. Olavs Plass, N-0130 Oslo, Norway |
| Abstract: | Agelasine F has previously been isolated from marine sponges (Agelas sp.) and has been associated with various bioactivities including inhibitory activity on Mycobacterium tuberculosis. No total synthesis of this natural product has been reported. ent-Agelasine F has now been synthesized for the first time, starting from (R)-pulegone. The synthesis is considerably more efficient than a previously reported route to rac-agelasine F. ent-Agelasine F is found to exhibit antimicrobial activity. |
| Keywords: | Agelasine Antimicrobial Natural product synthesis Pulegone |
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