Di-tert-butyl dicarbonate: a versatile carboxylating reagent |
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| Authors: | John Kallikat Augustine Y Arthoba Naik Sharmila Narasimhan |
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| Institution: | a Syngene International Ltd, Biocon Park, Plot No. 2 & 3, Bommasandra-Jigani Road, Bangalore 560 099, India
b Department of Studies in Chemistry, Kuvempu University, Shankaraghatta, Shimoga 577 451, India |
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| Abstract: | Carbon nucleophiles generated by a non-nucleophilic base (LDA) were effectively trapped with di-tert-butyl dicarbonate (Boc-anhydride) to provide the corresponding tert-butyl aryl acetates, di-tert-butyl aryl malonates, unsymmetrical aryl malonates and tert-butyl benzoates in high yields. This reaction represents another useful way to prepare a variety of tert-butyl carboxylates and highlights the synthetic utility of di-tert-butyl dicarbonate as a versatile carboxylating reagent. |
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| Keywords: | Carbon nucleophile Boc-anhydride Carboxylating reagent Non-nucleophilic base Di-tert-butyl malonate |
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