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Synthesis of novel deuterium labelled derivatives of N-alkylated polyamines |
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| Authors: | Merja R Häkkinen Tuomo A Keinänen Seppo Auriola Leena Alhonen Jouko Vepsäläinen |
| Institution: | a Department of Biosciences, Laboratory of Chemistry, Biocenter Kuopio, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland b Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland c Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia d Department of Pharmaceutical Chemistry, Biocenter Kuopio, University of Kuopio, PO Box 1627, FI-70211 Kuopio, Finland |
| Abstract: | Novel di-, tetra- and octadeuterated derivatives of mono-N-alkylated diaminopropanes, spermidines, spermines, symmetrically bis-N-alkylated spermines and unsymmetrically bis-N-alkylated spermines were synthesized. Deuterium labels were introduced into the RHNCH2CH2CN intermediate either by exchanging the protons next to the nitrile group under basic conditions with D2O-EtOD mixture or/and by reducing the nitrile group to a CD2-NH2 fragment with LiAlD4. |
| Keywords: | Polyamines Deuterated polyamines Deuterated N-Alkylated polyamine analogues |
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