Solvent-free synthesis of penta-substituted pyrroles: one-pot reaction of amine, alkyl acetoacetate, and fumaryl chloride |
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Authors: | Abdolali Alizadeh Mohadese Babaki Nasrin Zohreh |
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Affiliation: | Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran |
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Abstract: | A novel, convenient, and efficient approach to the synthesis of penta-substituted pyrroles has been reported based on the multicomponent reaction. Solvent-free condition for the formation of enaminones from primary amines and alkyl acetoacetates and it's reaction with fumaryl chloride lead to the formation of pyrroles that have halide, CH2CO2H, ester functional groups, and two alkyl substitutions. |
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