An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles |
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| Authors: | Schneekloth John S Kim Jimin Sorensen Erik J |
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| Institution: | Department of Chemistry, Princeton University, Frick Chemical Laboratory, Princeton, NJ 08544, USA |
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| Abstract: | In a variation of the classical Ugi reaction, an acid-promoted reaction between imines and isocyanides forms both 3-aminoindoles and substituted indoxyls. A recently reported triflyl phosphoramide is shown to be critical to obtain high yields under mild conditions. |
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| Keywords: | Multicomponent reactions Synthetic methods Isocyanides Heterocycles |
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