Fiber-coupled Al2O3:C radioluminescence dosimetry for total body irradiations |
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| Institution: | 1. Department of Physics, Federal Institute of Education, Science and Technology of São Paulo, São Paulo, SP 0110910, Brazil;2. Department of Materials Science and Engineering, Clemson University, Clemson, SC 29634, USA;1. University of the Witwatersrand, School of Physics, 1 Jan Smuts Avenue, Braamfontein, 2000 Johannesburg, South Africa;2. Center of Excellence in Strong Materials, Physics Building, University of the Witwatersrand, Johannesburg 2050, South Africa;3. iThemba Labs, Gauteng, 514 Empire Rd, Johannesburg, South Africa;1. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;3. The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA;4. Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA;1. Center for Nuclear Technologies, Technical University of Denmark, Frederiksborgvej 399, DK-4000 Roskilde, Denmark;2. Department of Oncology, Division of Radiotherapy (52AA), Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, DK-2730 Herlev, Denmark;1. Instituto de Física Arroyo Seco (UNCPBA) and CIFICEN (UNCPBA-CICPBA-CONICET), Pinto 399, 7000 Tandil, Argentina;2. Instituto de Física del Sur (IFISUR), Departamento de Física, UNS-CONICET, Argentina;1. Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire;2. Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire;3. Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire |
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| Abstract: | In vivo dosimetry can be important and relevant in radiotherapy, especially when commissioning new treatment techniques at hospitals. This study investigates the potential use of fiber-coupled radioluminescence (RL) dosimetry based on Al2O3:C or organic plastic scintillators for this purpose in the context of Total Body Irradiations (TBIs) where patients are treated with large fields of 6 or 18 MV photons at an extended source-to-surface distance (SSD). The study shows that Al2O3:C dosimetry using the saturated-RL protocol may be suitable for real-time in vivo dosimetry during TBI treatments from the perspective of the good agreement with alanine dosimetry and other critical phantom tests, including the ability to cope with the large stem signal experienced during TBI treatments at extended SSD. In contrast, the chromatic stem removal technique often used for organic plastic scintillators did not work well in large fields with the tested calibration procedure and instrumentation. An apparent dose-rate effect discussed in a previous study of the RL properties of Al2O3:C (Andersen et al., 2011) was found to have resulted from an overlooked dead time problem in the counting system, and this potential caveat can therefore be removed from the list of potential problems associated with fiber-coupled Al2O3:C dosimetry using the saturated-RL protocol. This further has implications for TBI dosimetry using the RL Al2O3:C system due to large dose-rate differences between calibrations at the iso-center and in vivo measurements at extended source-to-surface distances. |
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| Keywords: | Optical fiber Medical dosimetry Scintillator Total body irradiation In vivo |
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