Ultrasound responsive block copolymer micelle of poly(ethylene glycol)–poly(propylene glycol) obtained through click reaction |
| |
| Institution: | 1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;2. Children''s Hospital of Nanjing Medical University, Nanjing 210008, China;3. Department of Professional Institute, China Pharmaceutical University, Nanjing 210009, China;1. Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings, SD, 57007, USA;2. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Sector 67, Mohali, Punjab, 160062, India;1. Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China;2. Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, China;1. Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, United States;2. Department of Chemistry, Duke University, Durham, NC 27708, United States;3. Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, United States;4. Department of Polymer Science, University of Akron, Akron, OH 44325, United States |
| |
| Abstract: | The well-defined amphiphilic poly(ethylene glycol)-block-poly(propylene glycol) copolymer containing 1, 2, 3-triazole moiety and multiple ester bonds (PEG-click-PPG) was prepared by click reaction strategy. The PEG-click-PPG copolymer can self-assemble into spherical micelles in aqueous solution. It is found that high intensity focused ultrasound (HIFU) can open the copolymer PEG-click-PPG micelles and trigger the release of the payload in the micelle. The multiple ester bonds introduced in the junction point of the copolymer chain through click reactions were cleaved under HIFU, and leads to the disruption of the copolymer micelle and fast release of loaded cargo. The click reaction provides a convenient way to construct ultrasound responsive copolymer micelles with weak bonds. |
| |
| Keywords: | “Click” chemistry Block copolymer Self-assembly HIFU Mechanochemical |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
