Catalyst-free sonosynthesis of highly substituted propanamide derivatives in water |
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| Institution: | 1. Department of Chemistry, University of Zanjan, P O Box 45195-313, Zanjan, Iran;2. School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea;1. Periyar Maniyammai University, Vallam, Thanjavur, India;2. St. Francies College, Bangalore, India;3. Department of Physics, Tagore Arts College, Puducherry, India;4. Department of Physics, Bharathidasan Govt. College for Women, Puducherry, India;5. Department of Physics, Periyar Maniyammai University, Vallam, Thanjavur, India;1. Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal, Private Bag X01, Scottsville 3209, South Africa;2. Laboratory of Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium;3. Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium;4. Institute of Organic Chemistry and Biochemistry AS CR, v.v.i., Flemingovo nám. 2., 166 10, Prague 6, Czech Republic;1. Department of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721, USA;2. Department of Pharmacology, University of Arizona, Tucson, AZ 85721, USA |
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| Abstract: | A clean, rapid and energy-efficient approach to catalyst-free one-pot synthesis of highly substituted propanamide derivatives in water was developed utilizing of the ultrasonic irradiation. The method has been successful in achieving the green chemistry objective. A catalyst-free operation, an energy efficient protocol using ultrasound irradiation instead of conventional heating or stirring and use of water as a non-hazardous, inexpensive and readily available solvent in the one-step reaction against sequential reaction steps thus combining the features of both economic and environmental advantages. |
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| Keywords: | Ultrasound Isocyanide Propanamide Green synthesis Catalyst-free |
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