| Syntheses of DL-threo-Thiamphenicol via Green Oxidation |
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| 引用本文： | Robert Franzén. Syntheses of DL-threo-Thiamphenicol via Green Oxidation[J]. 高等学校化学研究, 2006, 22(5): 602-605. DOI: 10.1016/S1005-9040(06)60171-2 |
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| 作者姓名： | Robert Franzén |
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| 作者单位： | Institute of |
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| 摘 要： | IntroductionAqueous hydrogen peroxide is considered to be a“green”oxidant with a high oxidation efficiency due toits low molecular weight,cleanness in the oxidationprocess in which only harmless water is produced,lowcost of production and safe transport…
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| 关 键 词： | 绿色氧化 过氧化氢 钨酸钠 甲砜氯霉素 |
| 文章编号： | 1005-9040（2006）-05-602-04 |
| 收稿时间： | 2005-08-01 |
Syntheses of DL-threo-Thiamphenicol via Green Oxidation |
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| Kai LIU, Robert Franz,#xe;n, Xiao-jing YU, Jun ZHANG,You-jun XU. Syntheses of DL-threo-Thiamphenicol via Green Oxidation[J]. Chemical Research in Chinese University, 2006, 22(5): 602-605. DOI: 10.1016/S1005-9040(06)60171-2 |
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| Authors: | Kai LIU, Robert Franz n, Xiao-jing YU, Jun ZHANG,You-jun XU |
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| Affiliation: | aSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;bInstitute of Materials Chemistry, Tampere University of Technology, Korkeakoulunkatu 8, FIN-33720 Tampere, Finland |
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| Abstract: | Four methyl aryl thioethers related to thiamphenicol syntheses and methyl phenyl sulfide were cleanly oxidized into methyl sulfones in high to excellent yields via catalytic green oxidation with aqueous hydrogen peroxide in combination with sodium tungstate. When the same reactions were similarly performed in the absence of the catalyst, the corresponding sulfoxides could be obtained. This viable synthetic approach for the synthesis of DL-threo-thiamphenicol is a simple procedure, which has an economic advantage in view of its application for the large-scale synthesis because it can be carried out under mild conditions. |
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| Keywords: | Green oxidation Hydrogen peroxide Sodium tungstate Thiamphenicol |
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