TG/MS capillary interface |
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| Authors: | J. C. May A. V. Del Grosso R. M. Wheeler N. M. Etz |
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| Affiliation: | 1. Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, 20892, Bethesda, MD, USA
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| Abstract: | A TA Instruments Thermal Analysis System (TG) has been interfaced to the Hewlett Packard 5972 quadrupole mass spectrometer. An OSS-2 variable outlet splitter was plumbed between the TG and the mass spectrometer. This interface allows continuous monitoring of the ion intensities of mass peaksm/e=18 (water) andm/e=44 (carbon dioxide) used to elucidate the TG transitions attributable to residual moisture in freeze-dried biological products. Moisture specifications must be met in order to insure product stability throughout the approved shelf life. TG/MS results are discussed for BCG Vaccine, BCG Live (Intravesical) and U. S. Standard Antihemophilic Factor. Karl Fischer and TG/MS moisture results are compared. |
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