Cascade polycyclization: exploration of a convergent route to access various tricyclic and tetracyclic products related to sterols |
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| Authors: | Guay Benoit Deslongchamps Pierre |
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| Affiliation: | Département de Chimie, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, 3001, 12(e) Avenue nord, Sherbrooke, Québec J1H 5N4, Canada. |
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| Abstract: | The expedient synthesis of tricyclic and tetracyclic compounds via a cascade polycyclization methodology is described. Nazarov substrates (II) containing two Michael acceptors and a cyclohexenone ester (I) underwent cycloaddition followed by intramolecular 1,4-addition to furnish, in a highly stereoselective manner, tricyclic and tetracyclic products (III). Such compounds are interesting intermediates for the synthesis of polycyclic natural and unnatural products. |
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