Microbial metabolites of harman alkaloids |
| |
| Authors: | Herath Wimal Mikell Julie Rakel Ferreira Daneel Khan Ikhlas Ahmad |
| |
| Institution: | National Center of Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, MS 38677, USA. |
| |
| Abstract: | Several microorganisms showed the ability to transform the harman alkaloids, harmaline (1), harmalol (2) and harman (5). Harmaline (1) and harmalol (2) were converted by Rhodotorula rubra ATCC 20129 into the tryptamines, 2-acetyl-3-(2-acetamidoethyl)-7-methoxyindole (3) and 2-acetyl-3-(2-acetamidoethyl)-7-hydroxyindole (4), respectively. Harman (5) was biotransformed by Cunninghamella echinulata NRRL 3655 into 6-hydroxyharman (6) and harman-2-oxide (7). |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
