Solubility and glass transition in the system α-D-trehalose/water |
| |
Authors: | P. M. Mehl |
| |
Affiliation: | (1) Transfusion and Cryopreservation Research Program, NMRI, NNMC, Bldg 29 8901 Wisconsin Av., 20889-5607 Bethesda, MD, USA |
| |
Abstract: | Precipitation of trehalose dihydrate in water is observed at room temperature for trehalose concentrations higher than 47.5%w/w. Direct observations of crystal melting in water and measures of the solution density determine the thermal variations of trehalose saturationS(T) (mM) in water: ln(S(T))=ln(0.1223)-(1330/T) withR2=0.9982. The glass transition (Tg) curve measured by DSC is lower at low concentrations and higher at high concentrations than previously reported.Tg is also measured as a function of the cooling/warming rates. Analysis of specific heat changes atTg and associated activation energy leads to identify a most stable glassy state around the second eutectic concentration. |
| |
Keywords: | glass transition phase diagram solubility trehalose water |
本文献已被 SpringerLink 等数据库收录! |
|