Recent development and applications of semipinacol rearrangement reactions |
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| Authors: | Xiao-Ming Zhang Bao-Sheng Li Shao-Hua Wang Kun Zhang Fu-Min Zhang Yong-Qiang Tu |
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| Institution: | State Key Laboratory of Applied Organic Chemistry and School of Pharmacy, Lanzhou University, Lanzhou 730000 P. R. China ; School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030 P. R. China ; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen Guangdong 529020 P. R. China |
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| Abstract: | As has been well-recognized, semipinacol rearrangement functions as an exceptionally useful methodology in the synthesis of β-functionalized ketones, creation of quaternary carbon centers, and construction of challenging carbocycles. Due to their versatile utilities in organic synthesis, development of novel rearrangement reactions has been a vibrant topic that continues to shape the research field. Recent breakthroughs in novel electrophiles, tandem processes, and enantioselective catalytic transformations further enrich the toolbox of this chemistry and spur the strategic applications of this methodology in natural product synthesis. These achievements will be discussed in this minireview.The recent development of semipinacol rearrangement is reviewed, highlighting its application in β-functionalized ketone synthesis, quaternary carbon formation and total synthesis. |
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