New piperidine scaffolds via nucleophilic reactivity of (-)-phenyloxazolopiperidine |
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| Authors: | Poupon Erwan François David Kunesch Nicole Husson Henri-Philippe |
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| Institution: | Laboratoire de Pharmacognosie Associé au CNRS, UMR 8076 (BioCIS), Centre d'Etudes Pharmaceutiques, Université Paris-Sud 11, 5, Rue Jean-Baptiste Clément, 92296 Chatenay-Malabry CEDEX, France. |
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| Abstract: | The present work illustrates the power of compound 2 as a chiral, nonracemic, and stable 2-piperideine (enamine) equivalent in the rapid and efficient construction of 3-substituted piperidines (carbon-carbon and carbon-sulfur bonds) such as 3-spiropiperidines. This methodology offers a new route to such systems that could compete with previously reported strategies. |
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