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Stereoselective total synthesis of paecilomycin E and F and its two congeners Cochliomycin C and 6-epi-Cochliomycin C |
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| Authors: | Sudhakar Kadari Hemasri Yerrabelly Jayaprakash Rao Yerrabelly Thirupathi Gogula Yadaiah Goud Gangadhar Thalari |
| Institution: | Department of Chemistry, Osmania University, Hyderabad, India |
| Abstract: | An efficient and concise approach to the total synthesis of Paecilomycins E (1) and F (2), Cochliomycin C (4) and 6-epi-Cochliomycin C (3) is described. The synthesis involves novel route to the synthesis of Paecilomycin E and F and further conversion to Cochliomycin C and 6-epi-Cochliomycin C. Olefin metathesis and base promoted macro lactonization being the key reactions followed by chlorination to achieve target Cochliomycin C and 6-epi-Cochliomycin C. |
| Keywords: | C–C coupling Grignard reaction macrolactonisation natural products olefin metathesis total synthesis |