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Alternative total synthesis of (+)-aspicilin |
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| Authors: | Sridhar Musulla Bharathi Kumari Y Mahesh Madala Srinivasa Rao A Vema Venkata Naresh |
| Institution: | 1. Medicinal Chemistry Laboratories, GVK Biosciences Private Limited, Hyderabad, Telangana, India;2. Department of Chemistry, JNT University, Hyderabad, Telangana, India;3. Department of Chemistry, JNT University, Hyderabad, Telangana, India |
| Abstract: | The total synthesis of an 18-membered polyhydroxylated macrolide (+)-Aspicilin was accomplished starting from commercially available enantiopure propylene oxide and D-(+)-gluconolactone by asymmetric synthetic approach. The key reactions involved are Witttig reaction, Sharpless asymmetric dihydroxylation, and Yamaguchi macrolactonization. |
| Keywords: | Aspicilin S-propylene oxide sharpless asymmetric dihydroxylation and Yamaguchi macrolactonization witttig olefination |