Synthesis and evaluation of antitrypanosomal activity of some thiosemicarbazide derivatives of 1-butyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
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| Authors: | Andriy Pyrih Michael Berninger Andrzej Gzella Ulrike Holzgrabe |
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| Institution: | 1. Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;2. Institute of Pharmacy and Food Chemistry, University Wuerzburg, Am Hubland, Germany;3. Department of Organic Chemistry, Poznan University of Medical Sciences, Poznan, Poland |
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| Abstract: | The synthesis of thiosemicarbazide of 1-butyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid as well as its heterocyclic derivatives – 1,3,4-thiadiazole and 1,2,4-triazole are described; the modification of proper 1,2,4-triazole derivative by maleimides is also presented. Spectral properties of the prepared compounds and X-ray analysis for the selected compounds were studied. For the compounds antitrypanosomal potential and the toxicity were determined. |
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| Keywords: | 1 2 4-Triazoles 1 3 4-thiadiazoles antitrypanosomal activity fluoroquinolones X-ray analysis |
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