Synthesis of 4,6-diarylpyrimidin-2(1H)-one derivatives from benzyl halides and (1-bromoethyl)benzene under solvent-free conditions |
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| Authors: | Mallappa Beerappa |
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| Affiliation: | Department of Chemistry, Central College Campus, Bangalore University, Bangalore, Karnataka, India |
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| Abstract: | A facile synthesis of a series of pyrimidinone derivatives from the reaction of benzyl halides, (1-bromoethyl)benzene and urea in the presence of pyridine N-oxide (PNO) under solvent-free conditions is described. This transformation presumeably occurs via oxidation/cross-aldol condensation/Michael addition/intra molecular cyclization, domino sequence, involving the formation of one C–C bond and two C–N bonds in a single step. |
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| Keywords: | Biginelli reaction multi component reaction one-pot synthesis pyrimidine pyridine pyridine N-oxide |
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