Wang resin-supported sulfonic acid-catalyzed multicomponent reaction in water leading to 4-oxo-4,5,6,7-tetrahydroindole derivatives |
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Authors: | Naresh Kumar Reddy Dinne S Pulla Reddy Ganesh Yaddanapudi Sesha Siva Chandrasekhar Kothapalli Bannoath |
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Institution: | 1. Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Miyapur, Hyderabad, Telangana, India;2. College of Engineering, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India;3. College of Engineering, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, India |
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Abstract: | A greener approach for the synthesis of 4-oxo-4,5,6,7-tetrahydro indole derivatives has been achieved through Wang-OSO3H-mediated three-component reaction involving dimedone, phenacyl bromide, and primary amine in water. A variety of indole derivatives were prepared using this operationally simple and straight forward methodology in acceptable yields. |
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Keywords: | Dimedone multicomponent reactions (MCR) phenacyl bromide tetrahydro indoles Wong-OSO3H |
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