| 3-甲酰腙一利福霉素SV及其异构体的研究 |
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| 引用本文： | 王作琴,王桂芳.3-甲酰腙一利福霉素SV及其异构体的研究[J].波谱学杂志,1994,11(2):187-194. |
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| 作者姓名： | 王作琴 王桂芳 |
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| 作者单位： | 1. 沈阳化工研究院, 沈阳 110021;2. 东北制药总厂 |
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| 摘 要： | 用发酵和化学法合成的两个3-甲酰腙-利福霉素SV样品(1#,2#)具有不同的物理化学性质,本文用多种NMR技术,如1H,13C,DEPT,1H-1H COSY,反相摸式的1H-13C COSY及远程1H-13C COSY,并结合红外及紫外一可见光谱测试结果进行综合分析,确定样1#及样2#分别为酰胺式主产品及亚胺醇式导构体。根据实验结果对样1#的异构化反应进行了初步的探讨.
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| 关 键 词： | 3-甲酰腙-利福霉素SV 异构化 2D NMR 红外光谱 紫外-可见光谱 |
| 收稿时间： | 1993-05-07 |
THE STUDY OF 3-FORMHYDRAZONE-RIFAMYCIN SV AND ITS ISOMER |
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| Wang Zuoqin,Wang Gulfang,Gu Yushan.THE STUDY OF 3-FORMHYDRAZONE-RIFAMYCIN SV AND ITS ISOMER[J].Chinese Journal of Magnetic Resonance,1994,11(2):187-194. |
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| Authors: | Wang Zuoqin Wang Gulfang Gu Yushan |
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| Institution: | 1. Shenyang Institute or Chemical Industry, Shenyong 110021;2. The Northeast General Pharmaceutical Factory |
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| Abstract: | Two samples(1#,2#)of 3-formhydrazone-rifamycin SV produced by fermentation and chemieal modification have different physical and chemical properties.In this paper,their structures were determined by various kinds of NMR spcctra, such as 1H,13C,DEPT,1H-1H COSY,1H-13C COSY and LR 1H-13 C COSY in inverse mode, and by the absorption spectra of IR and UV-Vis.It was found that the two samples were the main product of amide mode (1#) and the isomer of iminol mode (2#). Based on the results of experiments,the isomerization of sample 1# was discussed. |
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| Keywords: | 3-formhydrazone-rifamycin SV Isomerization 2D NMR IR UV-Vis |
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