| Asymmetric Syntheses Aided by Biocatalysts |
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| 引用本文： | 陈沛然 顾建新 魏志亮 韩世清 李祖义 林国强. Asymmetric Syntheses Aided by Biocatalysts[J]. 中国化学, 2003, 21(8): 983-993. DOI: 10.1002/cjoc.20030210802 |
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| 作者姓名： | 陈沛然 顾建新 魏志亮 韩世清 李祖义 林国强 |
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| 作者单位： | ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,China |
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| 基金项目： | theNationalNaturalScienceFoundationofChinaandStateMinistryofScienceandTechnology (No .G2 0 0 0 0 775 0 6) |
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| 摘 要： | This article summarizes the achievements of the authors‘ group in the area of biocatalyst-catalyzed organic reactions in recent 10 years. A strain of Geotrichum sp. obtained by screeninu is capable of stereoselectlvely reducing a number of carbonyl compounds. In many cases, the stermghemistry is complementary with that obtained by baker‘ s yeast. Therefore, this microorganism provides a useful pathway to the preparation of alcohol eompounds with specific configurations. On the other hand, a nmmber of plant sourees have been screened for oxynitrilases and the hydrocyanation reactions of various arylcarboxalde-hydes have been investigated.A“micro-aqueous reaction system“ was invented,by which a serles of novel optically active cyanohydrins were prepared.On this hasis,a high through-put comtimasous reaction system has been designed.This paper also deseribes examples of the syntheses of bio-active compounds by using the optieally active compounds obtained from the above mentioned catalytic reactions as precursors.
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| 关 键 词： | 不对称合成 生物催化剂 立体选择性还原 氧腈酶 对映选择氢氰化 有机反应 |
Asymmetric Syntheses Aided by Biocatalysts |
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| Chen,Pei‐Ran,Gu, Jian‐Xin,Wei, Zbi‐Liang,Han, Shi‐Qing,Li, Zn‐Yi,Lin, Guo‐Qiang. Asymmetric Syntheses Aided by Biocatalysts[J]. Chinese Journal of Chemistry, 2003, 21(8): 983-993. DOI: 10.1002/cjoc.20030210802 |
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| Authors: | Chen Pei‐Ran Gu Jian‐Xin Wei Zbi‐Liang Han Shi‐Qing Li Zn‐Yi Lin Guo‐Qiang |
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| Abstract: | This article summarizes the achievements of the authors' group in the area of biocatalyst‐catalyzed organic reactions in recent 10 years. A strain of Geotrichum sp. obtained by screening is capable of stereoselectively reducing a number of carbonyl compounds. In many cases, the stereochemistry is complementary with that obtained by baker' s yeast. Therefore, this microorganism provides a useful pathway to the preparation of alcohol compounds with specific configurations. On the other hand, a number of plant sources have been screened for oxynitrilases and the hydrocyanation reactions of various arylcarboxaldehydes have been investigated. A “micro‐aqueous reaction system” was invented, by which a series of novel optically active cyanohydrins were prepared. On this basis, a high through‐put continuous reaction system has been designed. This paper also describes examples of the syntheses of bio‐active compounds by using the optically active compounds obtained from the above‐mentioned catalytic reactions as precursors. |
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| Keywords: | asymmetric synthesis biocatalyst Geotrichum sp. stereoselective reduction oxynitrilase enantioselective hydrocyanation |
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